mStab1-1.26, InVivoPure+

ID: AK726P+ Category:

mStab1-1.26, InVivoPure+ is a mouse monoclonal antibody against mouse Stabilin-1 (UniProt
entry: Q8R4Y4), also known as Clever-1 or FEEL-1.

The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-G affinity chromatography.

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Endotoxin level ≤ 1 EU/mg

mStab1-1.26, InVivoPure+ is a mouse monoclonal antibody against mouse Stabilin-1 (UniProt
entry: Q8R4Y4), also known as Clever-1 or FEEL-1. Stabilin-1 is a scavenger receptor expressed
by sinusoidal endothelial cells (ECs) in the liver, lymph nodes, spleen, and bone marrow [1].
Stabilin-1 is expressed in human breast cancer and supports tumor growth [2]. It is found on
subset of macrophages that mediate tissue homeostasis and is involved in liver fibrosis [3].
mStab1-1.26 or mStabilin-1 (clone 1.26) is first mentioned by Schledzewski et al. (2006) [4]. To
generate the antibody, a recombinant mouse stabilin-1 fragment (residues 1–710 of Q8R4Y4)
fused to mouse IgG2b-Fc was purified from stably-transfected HEK293 cells and used to
immunize stabilin-1 knockout mice. mStab1-1.26 recognizes stabilin-1 in rat and mouse.

The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-G affinity chromatography.

 

Product-ID: AK726P+
Immunogen: Recombinant mouse Stabilin-1 fragment from HEK 293
(residues 1–710 of Q8R4Y4, fused to mouse-IgG2b-Fc)
Host: Mouse
Clonality: Monoclonal
Isotype: Mouse IgG1κ
Formulation: Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 1.00 mg/ mL
Purity: ≥ 90% (CGE, reducing conditions)
Endotoxin: ≤ 1 EU/ mg (LAL test)
Recommended Isotype Control: Mouse IgG1- Antibody (AK3421)

 

The product is for research use or for further manufacturing only.

Additional information

Literature

[1] O. Politz et al., “Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues,”
Biochem. J., vol. 362, no. 1, pp. 155–164, 2002, doi: 10.1042/0264-6021:3620155.
[2] V. Riabov et al., “Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary
adenocarcinoma mouse model,” Oncotarget, vol. 7, no. 21, pp. 31097–31110, 2016, doi:
10.18632/oncotarget.8857.
[3] P. Rantakari et al., “Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis
and prevent fibrosis in chronic liver injury,” Proc. Natl. Acad. Sci. U. S. A., vol. 113, no. 33, pp. 9298–9303, 2016,
doi: 10.1073/pnas.1604780113.
[4] K. Schledzewski et al., “Lympathic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-
1+, F4/80+, CD11b+ macropahages in malignant tumours and wound healing tissue in vivo and in bone
marrow cultures in vitro: Implications for the assessment of lymphangiogenesis,” J. Pathol., vol. 209, no. 1, pp.
67–77, 2006, doi: 10.1002/path.1942.
Product citations

1.
Manta CP, Leibing T, Friedrich M, Nolte H, Adrian M, Schledzewski K, et al. Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression. Circulation. 2022;146(23):1783–99.
2.
Dunkel J, Viitala M, Karikoski M, Rantakari P, Virtakoivu R, Elima K, et al. Enhanced antibody production in clever-1/Stabilin-1-deficient mice. Front Immunol. 2018;9(OCT):1–11.
3.
Karikoski M, Marttila-Ichihara F, Elima K, Rantakari P, Hollmén M, Kelkka T, et al. Clever-1/stabilin-1 controls cancer growth and metastasis. Clin Cancer Res. 2014;20(24):6452–64.
4.
Karikoski M, Irjala H, Maksimow M, Miiluniemi M, Granfors K, Hernesniemi S, et al. Clever‐1/Stabilin‐1 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation. Eur J Immunol [Internet]. 2009 Dec;39(12):3477–87.
5.
Schledzewski K, Falkowski M, Moldenhauer G, Metharom P, Kzhyshkowska J, Ganss R, et al. Lympathic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macropahages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: Implications for the assessment of lymphangiogenesis. J Pathol. 2006;209(1):67–77.
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Product Information Sheet – AK726P+
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The product is for research use or for further manufacturing only.

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