HLA-DP/DQ/DR mAb (IVA12), InVivoPure+
The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II
molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of
an α (heavy) chain and a β (light) chain.
This antibody is produced exclusively under serum-free conditions from hybridoma and
purified with Protein-A or Protein-G affinity chromatography.
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Endotoxin level ≤ 1 EU/mg
The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II
molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of
an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells,
monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells
(APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3
complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis
lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS
express HLA-DR only.
This antibody is produced exclusively under serum-free conditions from hybridoma and
purified with Protein-A or Protein-G affinity chromatography.
| Product-ID: | AK3601P+ |
|---|---|
| Clone: | IVA12 |
| Immunogen: | Animals were immunized with the Priess human B cell line |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG1 κ |
| Formulation: | Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration: | ≥ 1.00 mg/mL |
| Purity: | ≥ 95 % (CGE, reducing conditions) |
| ≤ 5 % aggregates (analytical SEC) | |
| Endotoxin: | ≤ 1 EU/mg (LAL test) |
| Storage: | 2 - 8 °C |
| Recommended Isotype Control: | Mouse IgG1 ĸ Isotype Control (AK3421P+) |
The product is for research use only and not for use in diagnostic or therapeutic procedures.
The HLA-DP/DQ/DR monoclonal antibody (clone IVA12) was purified from supernatant of HB-145™ IVA12 from the ATCC. The ATCC trademark and trade name and any and all ATCC catalog numbers are trademarks of the American Type Culture Collection.
Additional information
| Literature | [1] Ulvestad E, Williams K, Bø L, Trapp B, Antel J, Mørk S. HLA class II molecules (HLA-DR, -DP, -DQ) on cells in the |
|---|---|
| Document | |
| Notice | The product is for research use only and not for use in diagnostic or therapeutic procedures. |
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