Anti-PCT clone P298-3-1-73-51

ID: AK2668 Category:

Anti-PCT clone P298-3-1-73-51 is a mouse monoclonal antibody against human Procalcitonin (PCT), a 116-amino acid peptide precursor of the hormone calcitonin, that is used as a biomarker to aid in diagnosis of bacterial infection or sepsis.

The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-A affinity chromatography.

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Anti-PCT clone P298-3-1-73-51 is a mouse monoclonal antibody against human Procalcitonin
(PCT), a 116-amino acid peptide precursor of the hormone calcitonin, that is used as a
biomarker to aid in diagnosis of bacterial infection or sepsis. PCT is produced after cleavage
of the 25-amino acid signal peptide from pre-procalcitonin (UniProt entry: P01258), the gene
product of the CALC-1 (CALCA) gene. PCT consists of three sections; the amino terminus (57
amino acids), immature calcitonin (33 amino acids) and katacalcin (21 amino acids).

In healthy individuals, transcription and translation of the CALC-1 gene is mostly confined to the
thyroid C-cells. However, in response to bacterial infection, mediated by cytokines interleukin-
6 (IL-6), tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-β), PCT production is activated
in all parenchymal tissues. These tissues lack the ability to cleave PCT to its mature form,
calcitonin, leading to accumulation of PCT. In addition, PCT production is attenuated by
interferon-γ primarily secreted in response to viral infection. This characteristic makes PCT a
specific marker for bacterial infection.

The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-A affinity chromatography.

 

Product-ID: AK2668
Immunogen: Human recombinant Procalcitonin
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b κ
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 0.5 mg/ mL
Purity: ≥ 90 % (CGE, reducing conditions), Two bands occur on the order of magnitude of the light chain
≤ 10 % aggregates (analytical SEC)
Storage: 2 - 8°C

 

The product is for research use or for further manufacturing only.

Additional information

Literature

[1] I. Samsudin and S. D. Vasikaran, “Clinical utility and measurement of procalcitonin,” Clin. Biochem. Rev., vol. 38,
no. 2, pp. 59–68, 2017.
[2] K. L. Becker, R. Snider, and E. S. Nylen, “Procalcitonin in sepsis and systemic inflammation: A harmful
biomarker and a therapeutic target,” Br. J. Pharmacol., vol. 159, no. 2, pp. 253–264, 2010, doi: 10.1111/j.1476-
5381.2009.00433.x.
[3] P. Linscheid et al., “In Vitro and in Vivo Calcitonin I Gene Expression in Parenchymal Cells: A Novel Product of
Human Adipose Tissue,” Endocrinology, vol. 144, no. 12, pp. 5578–5584, 2003, doi: 10.1210/en.2003-0854.
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Product Information Sheet – AK2668
Notice

The product is for research use or for further manufacturing only.

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