Anti-CEA clone 580/H6

ID: AK2178 Category:

Anti-CEA clone 580/H6 is a mouse monoclonal antibody against human Carcinoembryonic antigen (CEA) or CD66e, the product of the CEACAM5 gene (UniProt-ID: P06731).

The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography.

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Anti-CEA clone 580/H6 is a mouse monoclonal antibody against human Carcinoembryonic
antigen (CEA) or CD66e, the product of the CEACAM5 gene (UniProt-ID: P06731) [1]. CEA is
composed of an N-terminal variable (V)-like domain, followed by six constant C2-like domains
(N-A1-B1-A2-B2-A3-B3) and is attached to the membrane via a C-terminal GPI-anchor [2]. Due
to heavy N-glycosylation, its theoretical molecular weight of 71.3 kDa is increased to approx.
180-200 kDa [3]. CEA is not normally produced in significant quantities after birth but serum
levels are elevated in patients with colorectal cancer [4] or malignant breast tumors [5].

The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-G affinity chromatography.

 

Product-ID: AK2178
Immunogen: Human recombinant CEA
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1 ĸ
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 1 mg/ mL
Purity: ≥ 90% (CGE, reducing conditions)
≤ 10 % aggregates (analytical SEC)
Storage: 2 - 8°C

 

The product is for research use or for further manufacturing only.

Additional information

Literature

[1] K. Kuespert, S. Pils, and C. R. Hauck, “CEACAMs: their role in physiology and pathophysiology,” Curr. Opin. Cell
Biol., vol. 18, no. 5, pp. 565–571, 2006, doi: 10.1016/j.ceb.2006.08.008.
[2] N. Beauchemin and A. Arabzadeh, “Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in
cancer progression and metastasis,” Cancer Metastasis Rev., vol. 32, no. 3–4, pp. 643–671, 2013, doi:
10.1007/s10555-013-9444-6.
[3] K. Hatakeyama, K. Wakabayashi-Nakao, K. Ohshima, N. Sakura, K. Yamaguchi, and T. Mochizuki, “Novel
protein isoforms of carcinoembryonic antigen are secreted from pancreatic, gastric and colorectal cancer
cells,” BMC Res. Notes, vol. 6, no. 1, 2013, doi: 10.1186/1756-0500-6-381.
[4] C. Hall et al., “A review of the role of carcinoembryonic antigen in clinical practice,” Ann. Coloproctol., vol. 35,
no. 6, pp. 294–305, 2019, doi: 10.3393/ac.2019.11.13.
[5] Y. Fu and H. Li, “Assessing clinical significance of serum CA15-3 and carcinoembryonic antigen (CEA) levels in
breast cancer patients: A meta-analysis,” Med. Sci. Monit., vol. 22, pp. 3154–3162, 2016, doi:
10.12659/MSM.896563.
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Product Information Sheet – AK2178
Notice

The product is for research use or for further manufacturing only.

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