Anti-CEA clone 580/F4

ID: AK2180 Category:

Anti-CEA clone 580/F4 is a mouse monoclonal antibody against human Carcinoembryonic antigen (CEA) or CD66e, the product of the CEACAM5 gene (UniProt-ID: P06731).

The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography.

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Anti-CEA clone 580/F4 is a mouse monoclonal antibody against human Carcinoembryonic
antigen (CEA) or CD66e, the product of the CEACAM5 gene (UniProt-ID: P06731). CEA is
composed of an N-terminal variable (V)-like domain, followed by six constant C2-like domains
(N-A1-B1-A2-B2-A3-B3) and is attached to the membrane via a C-terminal GPI-anchor. Due
to heavy N-glycosylation, its theoretical molecular weight of 71.3 kDa is increased to approx.
180-200 kDa. CEA is not normally produced in significant quantities after birth but serum
levels are elevated in patients with colorectal cancer or malignant breast tumors.

The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-G affinity chromatography.

 

Product-ID: AK2180
Immunogen: Human recombinant CEA
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1 ĸ
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 1 mg/ mL
Purity: ≥ 90% (CGE, reducing conditions)
≤ 10 % aggregates (analytical SEC)
Storage: 2 - 8°C

 

The product is for research use or for further manufacturing only.

Additional information

Literature

[1] K. Kuespert, S. Pils, and C. R. Hauck, “CEACAMs: their role in physiology and pathophysiology,” Curr. Opin. Cell Biol., vol. 18, no. 5, pp. 565–571, 2006, doi: 10.1016/j.ceb.2006.08.008.
[2] N. Beauchemin and A. Arabzadeh, “Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis,” Cancer Metastasis Rev., vol. 32, no. 3–4, pp. 643–671, 2013, doi: 10.1007/s10555-013-9444-6.
[3] K. Hatakeyama, K. Wakabayashi-Nakao, K. Ohshima, N. Sakura, K. Yamaguchi, and T. Mochizuki, “Novel protein isoforms of carcinoembryonic antigen are secreted from pancreatic, gastric and colorectal cancer cells,” BMC Res. Notes, vol. 6, no. 1, 2013, doi: 10.1186/1756-0500-6-381.
[4] C. Hall et al., “A review of the role of carcinoembryonic antigen in clinical practice,” Ann. Coloproctol., vol. 35, no. 6, pp. 294–305, 2019, doi: 10.3393/ac.2019.11.13.
[5] Y. Fu and H. Li, “Assessing clinical significance of serum CA15-3 and carcinoembryonic antigen (CEA) levels in breast cancer patients: A meta-analysis,” Med. Sci. Monit., vol. 22, pp. 3154–3162, 2016, doi: 10.12659/MSM.896563.
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Product Information Sheet – AK2180
Notice

The product is for research use or for further manufacturing only.

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