Anti-CA15-3 Clone 136-116

ID: AK1148 Category:

Anti-CA15-3 Clone 136-116 is a mouse monoclonal antibody against human Cancer Antigen 15-3 (CA 15-3), a widely used serum tumor marker in patients with breast cancer.

The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography.

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Anti-CA15-3 Clone 136-116 is a mouse monoclonal antibody against human Cancer Antigen
15-3 (CA 15-3), a widely used serum tumor marker in patients with breast cancer [1]. CA 15-3
corresponds to the soluble form of the ~ 200 kDa transmembrane glycoprotein Mucin 1 (MUC
1) (UniProt-ID: P15941), which is produced through shedding of the MUC1 extracellular domain
or alternative splicing [2]. Serum levels of CA 15-3 and the tumor marker Carcinoembryonic
Antigen (CEA) have been shown to be elevated in patients with malignant breast tumors [3].

The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-G affinity chromatography.

 

Product-ID: AK1148
Immunogen: Native CA15-3 derived from a human cell line
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b κ
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 0.5 mg/ mL
Purity: ≥ 90% (CGE, reducing conditions)
≤ 10 % aggregates (analytical SEC)
Storage: 2 - 8 °C

 

The product is for research use or for further manufacturing only.

Additional information

Literature

[1] M. J. Duffy, D. Evoy, and E. W. McDermott, “CA 15-3: Uses and limitation as a biomarker for breast cancer,”
Clin. Chim. Acta, vol. 411, no. 23–24, pp. 1869–1874, 2010, doi: 10.1016/j.cca.2010.08.039.
[2] C. L. Hattrup and S. J. Gendler, “Structure and function of the cell surface (tethered) mucins,” Annu. Rev.
Physiol., vol. 70, pp. 431–457, 2008, doi: 10.1146/annurev.physiol.70.113006.100659.
[3] Y. Fu and H. Li, “Assessing clinical significance of serum CA15-3 and carcinoembryonic antigen (CEA) levels in
breast cancer patients: A meta-analysis,” Med. Sci. Monit., vol. 22, pp. 3154–3162, 2016, doi:
10.12659/MSM.896563.
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Product Information Sheet – AK1148
Notice

The product is for research use or for further manufacturing only.

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