ACE2-PD

ID: ACE2-PD_HEK Category:

Recombinant form of Angiotensin-converting enzyme 2 (ACE2), which is produced under serum-free conditions in HEK-INV cells (InVivo proprietary optimized; human embryonic kidney, HEK293 cells). ACE2 is the cellular receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV-2).

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InVivo offers a recombinant form of the peptidase domain (PD) of Angiotensin-converting enzyme 2 (ACE2), which is produced under serum-free conditions in HEK-INV cells (InVivo proprietary optimized; human embryonic kidney, HEK293 cells). ACE2 is the cellular receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV-2). The receptor-binding domain (RBD) of the SARS-CoV-2 Spike (S) protein interacts with the peptidase domain (PD, residues 19–615) of ACE2.

The construct contains residues 1–615 of ACE2, comprising the native signal peptide and the peptidase domain (PD). The mature protein is predicted to start with Gln18. The protein includes a C-terminal hexa-histidine-tag and is purified using immobilized metal exchange chromatography (IMAC).

 

Product-ID: RP_SZ_819
Expression System: Mammalian; HEK
Protein Acession Number: UniProt: Q9BYF1
Amino Acids: Met1–Asp615 (including signal peptide)
Mature Protein N-Term: Gln18 (predicted)
Tag: 6 x His-Tag; C-terminal
Expected Molecular Weight: 70.0 kDa (monomeric)
Formulation: Liquid ; 20 mM NaPP, 300 mM NaCl pH 7.2
Concentration: > 0.5 mg/ mL
Purity: > 90% (via analytical CGE under reducing conditions)
Specific Activity: ≥ 1 μmol/min/mg enzyme

 

The product is for research use or for further manufacturing only.

Additional information

Document

https://www.invivo.de/wp-content/uploads/2024/10/RP_SZ_819.pdf
Notice

The product is for research use or for further manufacturing only.

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