HLA-A2 mAb (BB7.2), InVivoPure
The BB7.2 monoclonal antibody is a well-characterized mouse IgG2b antibody that specifically recognizes HLA-A2, a major histocompatibility complex (MHC) class I molecule found in humans.
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
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Endotoxin level ≤ 2 EU/mg
The BB7.2 monoclonal antibody is a well-characterized mouse IgG2b antibody that specifically recognizes HLA-A2, a major histocompatibility complex (MHC) class I molecule found in humans. This antibody is widely used in immunological research, transplantation studies, and cancer immunotherapy.
BB7.2 binds to a conformational epitope of the HLA-A2 heavy chain, typically in association with β2-microglobulin (β2m). It does not cross-react with other HLA class I alleles, making it a valuable tool for distinguishing HLA-A2+ cells from non-HLA-A2+ populations.
HLA-A2 is an important molecule in tumor immunology, as many tumor-associated antigens (e.g., NY-ESO-1, MART-1) are presented by HLA-A2 to cytotoxic T lymphocytes (CTLs). The BB7.2 antibody serves as a critical reagent in screening and validating HLA-A2-restricted T-cell responses in cancer vaccine and T-cell therapy research.
The HLA-A2 mAb (BB7.2) can be used in Flow cytometry, immunoprecipitation and Western Blot, immunohistochemistry and functional blocking assay.
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
| Product-ID: | AK3625P |
|---|---|
| Clone: | BB7.2 |
| Immunogen: | Papain solubilized HLA-A2 |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | Mouse IgG2b |
| Formulation: | Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration: | ≥ 1.00 mg/mL |
| Purity: | ≥ 90 % (CGE, reducing conditions) |
| ≤ 10 % aggregates (analytical SEC) | |
| Endotoxin: | ≤ 2 EU/mg (LAL test) |
| Storage: | 2 - 8 °C |
| Recommended Isotype Control: | Mouse IgG2b ĸ Isotype Control (AK3456P) |
| Reported Application: | FACS ; IHC ; IF ; Fn |
The product is for research use only and not for use in diagnostic or therapeutic procedures.
Additional information
| Literature | [1] Parham P, Bodmer WF. Monoclonal antibody to a human histocompatibility alloantigen, HLA-A2. Nature. 1978 |
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| Document | |
| Notice | The product is for research use only and not for use in diagnostic or therapeutic procedures. |
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