CD4 mAb (GK1.5), InVivoPure+
The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule. The antibody profoundly blocks antigen specific murine class II MHC antigen reactive helper T lymphocyte lines.
This antibody is produced exclusively under serum-free conditions from hybridoma and purified with Protein-A or Protein-G affinity chromatography.
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Endotoxin level ≤ 1 EU/mg
The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface
receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic
cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important
role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4
associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is
blocked using the RM4-5 antibody by competing with GK1.5 for the same binding site on the
CD4 molecule. GK1.5 significantly enhanced the percentages of peripheral CD4+CD25+Foxp3+
Treg cells in CD4+ T cells in mice without altering their immunosuppressive function.
The antibody profoundly blocks antigen specific murine class II MHC antigen reactive helper T
lymphocyte lines.
This antibody is produced exclusively under serum-free conditions from hybridoma and
purified with Protein-A or Protein-G affinity chromatography.
| Product-ID: | AK3602P+ |
|---|---|
| Clone: | GK1.5 |
| Immunogen: | Animals were immunized with the cloned cytotoxic T lymphocyte lines V4 and 243/2.5. L3T4 is expressed on mouse helper/inducer T cells and is analogous to the human Leu-3/T4 molecule. |
| Host: | Rat |
| Clonality: | Monoclonal |
| Isotype: | IgG2b κ |
| Formulation: | Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration: | ≥ 1.00 mg/mL |
| Purity: | ≥ 95 % (CGE, reducing conditions) |
| ≤ 5 % aggregates (analytical SEC) | |
| Endotoxin: | ≤ 1 EU/mg (LAL test) |
| Storage: | 2 - 8 °C |
The product is for research use only and not for use in diagnostic or therapeutic procedures.
The CD4 monoclonal antibody (clone GK 1.5) was purified from supernatant of TIB-207™ GK1.5 from the ATCC. The ATCC trademark and trade name and any and all ATCC catalog numbers are trademarks of the American Type Culture Collection.
Additional information
| Literature | [1] Yi H, Zhen Y, Zeng C, Zhang L, Zhao Y. Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: influence |
|---|---|
| Document | |
| Notice | The product is for research use only and not for use in diagnostic or therapeutic procedures. |
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