HLA-DP/DQ/DR mAB (IVA12), InVivoPure

ID: AK3601P Category:

The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II
molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of
an α (heavy) chain and a β (light) chain.

This antibody is produced exclusively under serum-free conditions from hybridoma and
purified with Protein-A or Protein-G affinity chromatography.

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Endotoxin level ≤ 2 EU/mg

The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II
molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of
an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells,
monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells
(APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3
complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis
lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS
express HLA-DR only.

This antibody is produced exclusively under serum-free conditions from hybridoma and
purified with Protein-A or Protein-G affinity chromatography.

 

Product-ID: AK3601P
Clone: IVA12
Immunogen: Animals were immunized with the Priess human B cell line
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1 κ
Formulation: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration: ≥ 1.00 mg/mL
Purity: ≥ 90 % (CGE, reducing conditions)
≤ 10 % aggregates (analytical SEC)
Endotoxin: ≤ 2 EU/mg (LAL test)
Storage: 2 - 8 °C
Recommended Isotype Control: Mouse IgG1 ĸ Isotype Control (AK3421P)

 

The product is for research use only and not for use in diagnostic or therapeutic procedures.

The HLA-DP/DQ/DR monoclonal antibody (clone IVA12) was purified from supernatant of HB-145™ IVA12 from the ATCC. The ATCC trademark and trade name and any and all ATCC catalog numbers are trademarks of the American Type Culture Collection.

Additional information

Literature

[1] Ulvestad E, Williams K, Bø L, Trapp B, Antel J, Mørk S. HLA class II molecules (HLA-DR, -DP, -DQ) on cells in the
human CNS studied in situ and in vitro. Immunology. 1994 Aug;82(4):535-41. PMID: 7835916; PMCID:
PMC1414924.
[2] Zamoyska R. CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?
Curr Opin Immunol. 1998 Feb;10(1):82-7. doi: 10.1016/s0952-7915(98)80036-8. PMID: 9523116.
[3] Wang M, Tang ST, Stryhn A, Justesen S, Larsen MV, Dziegiel MH, Lewinsohn DM, Buus S, Lund O, Claesson
MH. Identification of MHC class II restricted T-cell-mediated reactivity against MHC class I binding
Mycobacterium tuberculosis peptides. Immunology. 2011 Apr;132(4):482-91. doi: 10.1111/j.1365-
2567.2010.03383.x. Epub 2011 Feb 7. PMID: 21294723; PMCID: PMC3075502.
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Product Information Sheet – AK3601P
Notice

The product is for research use only and not for use in diagnostic or therapeutic procedures.

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