Anti-CA15-3 Clone 136-115
Anti-CA15-3 Clone 136-115 is a mouse monoclonal antibody against human Cancer Antigen 15-3 (CA 15-3), a widely used serum tumor marker in patients with breast cancer.
The antibody is produced exclusively under serum-free conditions from hybridoma and purified through one-step purification with Protein-G affinity chromatography.
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Anti-CA15-3 Clone 136-115 is a mouse monoclonal antibody against human Cancer Antigen
15-3 (CA 15-3), a widely used serum tumor marker in patients with breast cancer [1]. CA 15-3
corresponds to the soluble form of the ~ 200 kDa transmembrane glycoprotein Mucin 1 (MUC
1) (UniProt-ID: P15941), which is produced through shedding of the MUC1 extracellular domain
or alternative splicing [2]. Serum levels of CA 15-3 and the tumor marker Carcinoembryonic
Antigen (CEA) have been shown to be elevated in patients with malignant breast tumors [3].
The antibody is produced exclusively under serum-free conditions from hybridoma and purified
through one-step purification with Protein-G affinity chromatography.
| Product-ID: | AK1147 |
|---|---|
| Immunogen: | Native CA15-3 derived from a human cell line |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG2b κ |
| Formulation: | Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered |
| Concentration: | ≥ 0.5 mg/ mL |
| Purity: | ≥ 90% (CGE, reducing conditions) |
| ≤ 10 % aggregates (analytical SEC) | |
| Storage: | 2 - 8 °C |
The product is for research use or for further manufacturing only.
Additional information
| Literature | [1] M. J. Duffy, D. Evoy, and E. W. McDermott, “CA 15-3: Uses and limitation as a biomarker for breast cancer,” |
|---|---|
| Document | |
| Notice | The product is for research use or for further manufacturing only. |
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